About one-third of humans are in sleep, which is an indispensable physiological need. However, as the pace of life accelerates, overtime and day and night have become the norm for many people to work.
Many studies have shown that lack of sleep can be harmful to the body in many ways. A natural journal study in 2019 adds another hazard: scientists at Harvard Medical School and Massachusetts General Hospital found that irregular sleep patterns accelerated the formation of atherosclerosis in laboratory mice.
Atherosclerosis is a serious disease. In the patient’s arteries, white blood cells invade the arterial wall and come into contact with substances such as cholesterol, causing an inflammatory reaction. This causes the arteries to develop plaque-like structures that narrow them. In severe cases, it can even cause coronary artery disease or stroke.
In this study, scientists wanted to understand the relationship between sleep and atherosclerosis. They used a special type of mouse that is naturally susceptible to atherosclerosis.
The researchers divided the mice into two groups: a group of “fragmented sleep” groups in which a stick gently swept through the bottom of the cage and awakened them as they slept, creating an artificial “fragmented” sleep. Another group of mice slept as a control without interference. The researchers then compared the physiology of the two groups and found that the mice in the fragmented sleep group had less atherosclerosis than the control group. If the mouse was swept with a stick while awake, there was no similar difference between the two groups. Therefore, the researchers confirmed that these physiological differences are indeed due to sleep disruption.
In addition to increasing the risk of atherosclerosis, sleep disruption increases the risk of dementia.
It turns out that brain waste is mainly composed of beta-amyloid. Scientific research has fully demonstrated that amyloid beta plaques in the brain are the main cause of Alzheimer’s disease. When these β-amyloid proteins are deposited in different parts of the brain tissue, they affect the function of nerve cells in the region, causing different neurological symptoms, including memory disorders, cognitive disorders, speech disorders, spatial visual impairments, mood disorders and and many more. It is worth noting that if there is not enough deep sleep, β-amyloid will accumulate in the brain, affecting the brain area that produces deep sleep. The resulting loss of deep sleep further hinders the removal of beta-amyloid from the brain at night, resulting in the accumulation of beta-amyloid and an endless downward spiral.
Adequate sleep but lack of sleep can increase the risk of Alzheimer’s disease. Therefore, only 7 to 8 hours of sleep a day is not enough, people need to pay more attention to the structure and quality of sleep. Sleep is divided into NREM stage and REM stage. The function of NREM is mainly to restore physical strength, especially in the deep sleep stage, accounting for 20% to 25% of the total sleep time. However, the function of REM is mainly to repair the nervous system and enhance memory function. The average night NREM and REM phases alternate four to six times. As you age, the proportion of deep sleep and REM stages will decrease.
The researchers studied the sleep structure of guinea pigs. This experiment used different doses of the dzopiclone group and placebo controls. The results showed that dzopicron increased the proportion of NREM sleep in guinea pigs at 1 mg / kg, 3 mg / kg and 10 mg / kg, and increased with increasing dose. The three dose groups had no effect on the REM stage of guinea pigs.
Domestic studies of sleep structure changes before and after taking dzopicron in PSG showed that dzopicron significantly reduced the first stage of sleep and increased the proportion of deep sleep in NERM.
Only with reasonable sleep time and structure can you get high quality sleep and ensure your health.